Time to get technical on your ass…

Evening Gorgeous xx

How are you all doing? You OK? Good, good.

** This article needs editing, but it’s 4am and I can’t be bothered – another day **

Right. I seem to be laying things out a lot straighter than I used to, then going off on a mission explaining myself. It something I’m good at and it’s not a personality trait I intend to lose and I quite like it. This post is no different; but this post comes as a surprise, to me at least. The back story, is I was writing another post; regarding something completely different – I’ll post it after this one but this one is to be pinned. This one is important.

So I’ll go back to the beginning; way back. I was 4 years old. I was struck ill with what I was told for a long time was Epilepsy and it was treated as that. Being different anyway, I was taunted and cursed by my peers for it. For years it was a curse over me. It’s one of the two reasons I was raped – Their taunts of ‘Eppy’ and ‘He’s Gay’ pretty much prove it. But I’m not Gay and I’m not Epileptic – At the time I didn’t know what I was. This produced a great deal of depression; which persists to this day – Even now I still take Fluoxetine at 40mg daily, Depression is a killer if not managed correctly.

It took me many years to come to terms with all that, however. The final trigger being me taking drugs for several years in the early 2000’s. One single event stands out from that though. An event where I popped a pill at well known Dance Festival (Creamfields in 2001 to be precise), and everything changed. The ‘Deja-Vu’ as I’ve become accustomed to calling it began in earnest. Now I’ve written about my Deja-Vu, in a previous post, and been unable to explain the phenomenon clearly; but we will come back to it shortly. I want to move on for a reason. In 2004 I came off drugs, realised I was raped, sorted out what I could and started to move on with my life. Great. Moved to Cambridge, had a son, all seemed OK – Not. Behind the scenes something was wrong and I’ve spent the last two years trying to work out what.

I split with my son’s mum in 2016 after a troubled end to a good relationship, not without its faults mind; but it was a good time in my life. I love my son very much and I miss him dearly – I’ll see him again soon. The split, however, lead me down a path that resulted in a diagnosis of Autism Spectrum Disorder, specifically Asperger Syndrome (AS) in September of that year.

This set off a chain of events which I have written about in previous posts and I’ll not recount. The result of those events, ultimately, is this blog. This has all been born out of my diagnosis of Gender Dysphoria in 2017, the resultant transition in the December and all the changes which have happened since. I’ve talked a lot about those changes as well and won’t repeat them here either.

In amongst all of that, I’ve had a fascination with brain function; especially my own. I’ve been looking for a connection that links everything together, as I’ve always believed these events and symptoms are related in some way – They all happen to me, lets be honest. So, in that case, what’s wrong with me? Why is my brain different? Why doesn’t it work in the same way as everybody else? Well I think I’ve got a reason for that – Something I never knew about before know that appears to connect everything together.

Meet the NMDAR, or N-Methyl-D-Aspartate Receptor – I said this was technical, didn’t I?

OK, so lets get started. NMDA is an Amino Acid derivative that is very similar to Glutamate, the brains primary excitatory neurotransmitter. NMDA was developed by pharmacologists in order to activate and identify a particular subtype of neurotransmitters in the brain, ideally those involved in synaptic plasticity and memory function of the cell, or basically 1/3 of what makes it tick (No I’m not going into detail).

What’s this got to do with me? OK, well; lets start with the fact that a cell receptor is activated by two different types of drug: The cell receptor Agonist and the Antagonist. The Agonist binds to a cell receptor and fully activates that receptor; thereby allowing it to work. The Antagonist also binds to the receptor but does not activate it, and can block the action of other Agonists – stopping the receptor from working. Reference this to the NMDA Receptor and we have two lists of drugs NMDA Agonists and NMDA Antagonists. This is very simplified and the science is much more detailed and complex, much beyond the scope of what I’m talking about.

We need to know the above to understand the lightbulb moment that happened when I read this blog post: Depersonalization in gender dysphoria: widespread and widely unrecognized. Why a lightbulb moment? Well, this paragraph in particular gripped me:

Speaking personally, I noticed the lifting of depersonalization symptoms within one to two weeks after beginning HRT, and this was something that I had simply never felt before – neither during previous transition milestones such as coming out and presenting as a woman full-time, nor at any other point. Nothing has ever come close before or since. The difference felt almost undeniably chemical; merely being excited about major events in my life had never caused such a noticeable and unexpected change. Scott at Slate Star Codex has also noted that estrogen can act on NMDA receptors, which are implicated in dissociative symptoms broadly, although the potential role of such a mechanism in gender dysphoria is highly speculative.

Note the highlighted words regarding NMDA receptors and you’re onto my thinking – Yeah, it’s tentative but there’s more. Off I went and followed the link and started reading about NMDA receptors and such and I found this paragraph:

Drugs that block NMDA receptors cause dissociation. The most famous dissociative anaesthetic, ketamine, is an NMDA antagonist. So is DXM, a recreational drug that causes dissociation in abusers. Wikipedia’s list of dissociative drugs is basically just fifty-five NMDA antagonists in a row. The only other category they list are kappa opioid agonists, and kappa opioid agonism probably – you guessed it – antagonize NMDA. If we take this result seriously, every substance we know of that causes dissociation is an NMDA antagonist in some way.

You dig me? Creamfields 2001 came into my head straight away – what else was in that E? That’s when the Deja-Vu started, interesting. We’re onto something here, more reading methinks… OK, read more information on disassociation and I started hitting words that I recognised; the likes of depersonalisation, derealisation and dysphoria. Hang on a second, what? Gender Dysphoria – Are you sure this link is speculative? Makes sense to me.

What tends to be the norm; is that NMDA Antagonists, at sub-anaesthetic doses cause the symptoms described above. The most famous NMDA Antagonist is Ketamine, a horse tranquiliser which is also known as the recreational drug ‘Special K’. Yeah OK, and? Well any drug worker will tell you that the most common mix of Ketamine is with Ecstacy, or E. See above.

Have I just explained my Deja-Vu, did it all come about after taking that tablet? Is it a symptom of Dysphoria? Well, possibly but there’s a problem. It should have subsided within a short space of time (maximum of two years, more likely six months). Oops, in the main it did; but mine carried on and still persists albeit VERY occasionally to this day.

So why did mine carry on? Did I miss something? Well yeah, I did. If you google NMDA, you’l come across the Wiki page for the NMDA Receptor (currently it lists just below the questions). Open up and read the page all the way down and you’ll hit this paragraph:

Cochlear NMDARs are the target of intense research to find pharmacological solutions to treat tinnitus. NMDARs are associated with a rare autoimmune disease, anti-NMDA receptor encephalitis, that usually occurs due to cross-reactivity of antibodies produced by the immune system against ectopic brain tissues, such as those found in teratoma. These are known as anti-glutamate receptor antibodies.

Hello! They told me it was Encephalitis and not Epilepsy in 2005! Are we going through another tenuous link of mine? Of course we are. But are you going to tell me there’s not something in this? Remember, it was 1976 when I had mine, and they didn’t have the technology they have today. Think.

I’m not done yet though, there’s one thing I’ve left out. And when you add it in, it all makes sense. Can you guess what it is? I’ve written about it before. Any Ideas?

Autism. Your awake then 🙂

Specifically the link between Trans Identity and Autism. Did I tell you I have Asperger Syndrome? I’m sure I did. Well, look; lets go back to that article on Slate Star Codex. You see, either I’m nuts or this article (and it’s counterparts) are answering a lot of questions. Right? OK, bear with me and go back to that article; the link is here if you missed it:

Why are Transgender People immune to optical illusions?

Oh, by the way, yes I was and in a way still am; immune to most optical illusions. It’s a problem that’s bugged me my whole life – Although I’ve noticed that it’s A LOT harder recently to see past them 🙂 Ask anyone who knows me… Right, off we go to part III of that article and we’ll do some more reading.

Read it yet? Because here’s the lightbulb moment for me:

So I wonder: is NMDA hypofunction related to transgender? That would explain the autism and schizophrenia connections. It would explain the hollow mask numbers. It would explain the dissociation. It would explain why estrogen helps the dissociation. And it would explain a lot of internal connections between all of these different conditions and factors.

And it explains the Encephalitis, fuck. It also gives an explanation to why my brother has been diagnosed with Schizophrenia after chronic, long-term Cannabis use. Could this be a genetic predisposition to NMDA Dysfunction? Who knows, but I’m off to have a chat with my GP!

Much Love,

 

Vikki xx


 

P.S. – For the sceptics:

Read section IV of the same article.

Thank you xx

Me, Myself & I…

Hello gorgeous xx

How are you all this morning? I hope you are well and enjoying life; as always. 🙂 – Me? I’m OK, I’ll be fine; of that I am sure. Don’t worry about me, I can take care of myself; promise…

So I’m writing down what I’m currently feeling and what’s going through my head. That’s what this blog is all about isn’t it? Me, my journey through this minefield we call sexual development? Where do I sit on this sexual spectrum?

Well you know what’s going through my head right now, regarding it all – those questions are clear, “What am I?” – Am I male, am I female, am I both or am I somewhere in between? Where do I sit on the sexual / gender spectrum? – I don’t know the answer.

And I should because shouldn’t everyone?

OK, let me put it this way; boys are boys and they know they’re boys, right?. Just as girls are girls, with me? Good. Well as I’m finding out, that’s not strictly true. Here’s the thing; Androgen Insensitivity Syndrome can turn what is effectively a male foetus, into a girl – with a Vagina. And Congenital Adrenal Hyperplasia can, in its rarest forms, turn a female foetus; into a boy, complete with Penis. Got you there, haven’t I? On top of that, there’s the previously mentioned SRY Gene mutation; probably responsible for C.A.H.

Now I use the terms ‘Male’ and ‘Female’, ‘Boy’ and ‘Girl’; loosely and using them indicates my lack of knowledge in this area, but I’m learning all the time. I have to. I’m on the gender spectrum somewhere as I wouldn’t be Trans if I wasn’t… Or would I? Well I’ll point to an earlier post to clear this up first, then I’ll move on.

Gender and Sex are different. Gender is presentation, Sex is biological. Gender on the outside, Sex on the inside. Gender is the clothes you wear, Sex (apart from how you feel about it) is your physical attributes and characteristics – Breasts, Penis, Vagina, etc.

And here’s my problem. (Does it always have to be about me? – Yes, it does, this is my blog; deal with it). Well the problem is I’ve always felt different, I’ve always known I’m different, but I’ve just never quite known ‘How’ I’m different. Never been able to work it out.

So in my quest to figure this shit out, I’ve come across many things, I’ve learnt an amazing amount of information; but I’ve never started to apply that properly to me. Only recently have sysrted to look at where I fit into this world and where I am on these sprectrums; now I know they exist. Well ok, the barriers are gone now; let’s have a look shall we?…

So there’s a BBC documentary, produced in 2011, called “Me, Myself and I”. The documentary focusses on intersex conditions, how they manifest themselves and how society has dealt with some of them. It introduces you to the idea that sex itself; is, in fact, a spectrum (Female at one end, Male at the other). That for the first seven weeks of our existence; we are ALL female. And that gender is a choice, and can be based on your sex, and is not always your choice to make – but it should be.

Watching the documentary made me cry, floods of tears- Tears of relief…

What the fuck?

Okay, so I’m throwing a long ball, and it’ll be a while before I know the answer, but things have bugged me throughout my life and they were passed off by people around me; as normal. When I was born, for example, everyone who saw me mistook me for a girl. My mum always said it. I’ve been brought up to think that happens, and it’s normal; there are perfectly normal males out there who were like that.

Then there’s the fact that I never developed a great deal of body hair; and that, when I was younger, I was told (by quite a lot of people) that I’d look much better as a girl – Never had a great deal of muscle mass, for example. Hmmm. Interesting point here.

Then finally, for me, there’s the fact that I couldn’t deal with male puberty. Androgens wreaking havoc on my body nearly killed me a number of times – I remember four separate suicide attempts, for example. When learning about Sex and my sexuaity, I was more comfortable with the female role (there’s a lot behind this but it’s incredibly disturbing and I’m not, and may never be, ready to release it publicly but if I must write something down; then yes I was poking things in places where it didn’t feel right at the time for them to go).

When you put that together, Gender Dysphoria is the right diagnosis. That much is obvious. But then when I look at my physical development, and pictures of me when I was a child, then was there something else going on that has been left undiagnosed?…

Again, I always knew I was different; and a lot of my family knew it, but I never knew how.

Much Love,

Vikki xx

Anniversary…

Morning Gorgeous xx

How are you all doing today? As usual, I hope it’s all good and you’re all doing fine…

Don’t just say that now, if you’re having a bad day; then I’ve always got an ear to bend, all you need to do is ask. Ok. Good. As for me, this is going to be a difficut weekend. One I have to get through and one I need to be strong for. Tough is not the word I’d use, in all honesty.

Why? You ask… Well, it’s a bittersweet weekend (and next week, actually). Did you know it’s one year since my breakdown? No? Well it is. It was one year ago this weekend that the old me finally broke down and gave up the ghost. Bert’s last dying breaths were taken and it was after this weekend; last year, that I knew I couldnt carry on.

My memory and understanding of that August Bank Holiday Monday, in the UK, is still very vague. I remember leaving work on the Friday and buying alcohol; exactly what I cant remember, and I’ve been told by a friend that we went at it hard-style until the Sunday morning. By hard style; we are good friends and know each other very well – She has been one of my rocks of support as I’ve gone through my transition so far. So when we get together, grab the alcohol, etc. and fire up the XBox; we have a good night in. We both miss those nights…

But she clearly remembers going home early on the Sunday; which doesn’t explain how I woke up in the position I did 48 hours later – I definitely hit it very, very, hard.

What did I do in those missing 48 Hours? Where did I go? Who did I speak to? There is no record of those events. There was nothing on my phone to suggest I’d arranged to meet someone, and there were no (as I can recall) phone records or WhatsApp conversations to any new numbers. It’s all a bit strange.

But then I work in IT and have done for 30 years now. I’ve also been very good at hiding things; especially from myself, the full details of the rape being one example. So If I can do that, then obviously I can hide what happened on this weekend –  that would be fairly easy.

Also of note, is that I don’t feel bad about that weekend. There’s no negative feelings around it; not like the rape. I don’t get any gut wrenching feelings in the bottom of my stomach when I think about it. And I don’t want to burst out in tears or lash out in anger about it either. I’m quite happy about it; actually. All of this conspires to tell me that whatever I did and whoever I saw, I had fun and I enjoyed it all.

In contrast to all that though, this weekend I’m in pain; physical pain – it hurts like hell. Whats happening is that I’m having injection site reactions to the drugs I’m on. The drugs themselves are working brilliantly, finally and I can think clearly; very clearly. I definitely feel more feminine and happier than I did before. But again, there is sadness this week. It’s my mothers funeral on Tuesday and I have to go home for that – that hurts like hell as well.

It makes me wonder why I’m not able to remember the good stuff, and the bad is as clear as day in my head? How is that fair? Because actually, when I look back through my life, it is easier to remember the bad stuff than the good stuff – It seems to stand out more. But explaining why, beyond what I already know, is hard work.

I had an amazing ounselling session on Friday, we covered a lot of ground in a short space of time. It was also very enlightening for both me and my counsellor. I’m sure I taught her a lot about various things to do with my Psyche, and when I need to learn a subject, I always try to become VERY knowledgeable on it. But I also learnt something new about myself, something I’d wondered for a while and now; I’m sure – very sure of it. That is that I probably have PTSD and other co-morbid conditions close to it.

Symptoms that I display within my Psyche are very common in patients with PTSD, although some are a little diferent within me. Others less so, but still fall within the category of PTSD Symptoms. In any event, they happen, and in my usual lengthy style; I find them difficult to explain.

So does going down the direct route of PTSD and related co-morbids; answer the fundamental differences in who I am ,and why my transition is different to most others? I don’t know. But it does answer the question of why the short, sharp, shock method has worked so very well. I’m repeating a trauma that happened many years ago and trying to resolve my inner feelings about it.

Well I think I have done. I think that those boys, on a mental level, didn’t rape a man. They raped a woman. That’s what I saw myself as at the time. I saw a woman in the mirror but I was forced to live in a mans body. And I didn’t like it. And it was trauma that has kept me there for so long.

Now I need to find out why. I know what this has all done to me, and the type of person I am now. What do I do with this? Where do I go from here???…

Much Love,

 

Vikki xx

Neurodiversity…

Afternoon gorgeous XX

Hope you’re all enjoying the weather we’re having here (assuming you’re here, near me), if not or you’re somewhere else; I hope life and the weather is good for you.

So this is the second post detailing my shift in thinking; which is occuring as I move further and further through my transition. As I do so, I’m seeing things differently, experiencing things differently and overall taking on a completely different attitude.

Which; ultimately, that’s what this is all about for me – a massive life change from Male, to Female. But the last post, and how it came about, has me thinking along different lines; it’s pointing to differences in how I see myself. With the big question being; “What am I?”.

Well, it’s obvious that the current school of thought sees Trans people as being on a spectrum. We’re all at a different point in the transition from one gender, to another, aren’t we? Or are we? Well, you see, that’s where the issue has been for me. And that’s also where the issue appears to lie for most Non-LGBT+ people, too.

I spent most of my life trying to fit in with a concept that I, ultimately, don’t agree with. And that is the concept of two genders and two sexes, Male and Female; Man and Woman. That was ingrained into me as a child because of where and how I was brought up. I was aware of Gays and Lesbians; but still you have the Male and Female elements of both. However, I now ask the question; is that strictly true?

Well, no matter what people think and no matter what people say, a large majority of the population will ultimately agree with the above. That’s changing as society comes to terms with the fact that Gender and Sex are two different things, but ultimately; human beings are Male and Female.

I’m not discounting Intersex people here, I’m just going a lot deeper than that. As I see intersex as a variation, or combination of the sex Chromosomes; X and Y – I am also aware that the sry gene from the Y chromosome can hop over to the X. Again, that is a variation on what could be considered the norm. So, to better explain myself; and give you an understanding of how I see it, think of people with Polychromatic Eyes…

Moving on; at birth, our parents first see us & our sex organs and; quite rightly, assume that we are to become the gender our sex organs define us as. If you’re a parent, think of that first response as your child is born; “It’s a boy!”, or “It’s a girl!” – “It’s Transgender and will have Vaginoplasty!” doesn’t quite sound the same, does it?…

And I have a son, and was present at his birth…

Ok. So I have your attention, in a very big way. What point am I trying to make?

I’ll tell you…

Trans people see themselves as being on a spectrum, there’s different points on the spectrum (cross dressing, HRT, Gender Surgery, etc.) and coming in from the outside; it’s very much like Autism. Which is also based on a spectrum – I know, I’m on it and have the diagnosis to prove it. So, it’s difficult for an outsider coming in to view Trans people correctly; because of the great variation within the spectrum. But society has come to accept (to a point) the greater LGBT+ community.

So, my thinking is; why don’t we just look at the greater LGBT+ community as being on the same spectrum; from Male to Female. Then include everybody on that spectrum; Lesbian, Gays, Crossdressers, Transsexuals, etc., and call us all Trans? No more separation, no more LGBT, just Transgender. Which, in a way, is what we are?

You then have a complete sexual and gender spectrum from which a person can move along and stop at what point they see fit, at any point in their life. It also makes it much easier for an outsider to understand what is happening within the spectrum community, they don’t need to understand labels anymore; just that someone is Transgender. Much like someone who is Autistic is Neurodiverse? I’ll tell this, that kind of thinking sure as hell makes it a lot easier for me to understand.

Moving forward th that; we, as humans, can then be born Male, Female or Intersex and then become a part of that spectrum and choose our gender as we progress and grow through life.

Much like what is happening with me.

Much Love,

Vikki xx

Gender Identity…

Morning gorgeous XX

How are you all today? Did to get out of bed the right side? Good. If not, I feel you; but go back to bed right now and get out of the other side please! Lol. Seriously, it’s not pleasant when you wake up to a bad morning, I’ve had many of them in the past and I don’t envy you at all.

The reality for me this morning; though, is that today is a good day. I had my injection yesterday and my stomach hurts. But the doctor, a younger Asian lady who’s name I forget, was a brilliant doctor and we hit it off really well. She even shown me how to do the injection myself. We got on that well that I nearly invited her over for a glass of wine and a natter about being Trans. (If you’re reading this doc, the offers still open; give me a shout! – oops!).

But what she said got me thinking about what it’s like to be Trans, and what does Trans actually mean. It got me thinking about how the Trans world currently sees itself and how I, as an individual, see myself within it.

I read a lot about the different types of thinking within the Trans community – The old skool 1990s train of thought, the new age of inclusivity, the gender wars of the early 2000’s, etc., and it’s a lot to take in all at once. Reading it all makes me wonder just how the rest of society is coping with all this. I mean; I wrote this blog so I could understand it because it’s difficult and I’ve got an IQ of 142 (or thereabout)!

Then I read something this morning, it was a post about ‘detransitioning’ – a term used in the Trans community to mean someone who is going back to their original gender (or going off HRT, which I am on). And there’s a lot of discussion in that area, with some very intellectual thinking; judging by the post I read.

Anyhow, I’ve copied the link here because it’s relevant. It’s relevant to my train of thought, it’s relevant to where my head is at and it’s something I feel I need to understand.

We’ll to give you an idea; my current train of thought is this…

“Now that I have experienced contentment in my thoughts, do I stop here? Or do I carry on and complete the transition?”

Which has got me thinking as to exactly what my transition means to me. How far do I want to go? What do I want to achieve? Who do I want to be?

Time to work that out I think. But in the meantime, take a look at the link below and see what you think. What does it suggest to you?

https://www.quora.com/I-m-transgender-and-what-if-I-take-HRT-and-don-t-like-who-I-am-after-is-there-a-way-of-reverting/answer/Virginia-Hall-12?share=faa9b504&srid=mlqa

Answers on a postcard…

Ps. Just to ally the critical mind. This post doesn’t mean that I, personally, am thinking of detransitioning – Far from it. But it does indicate a change in thought processes. Which is something I’m going to tackle in my next post.

Much love,

Vikki xx